diff --git a/figure1.png b/figure1.png index 047a68c..2b39991 100644 Binary files a/figure1.png and b/figure1.png differ diff --git a/figure3.png b/figure3.png index aa647c7..8b03410 100644 Binary files a/figure3.png and b/figure3.png differ diff --git a/wholeBrain_main.md b/wholeBrain_main.md index d0c660a..5832a9d 100644 --- a/wholeBrain_main.md +++ b/wholeBrain_main.md @@ -41,7 +41,7 @@ Neocortical organization consists of cortical modules tiled across the cortical * Calcium imaging-- Konnerth 'waves' in Ent cortex [#Adelsberger:2005]. For visual cortex, domains activity in extrastriate cortex (Ackman Nature 2012). But S1-- [#Golshani:2009] work in later postnatal-- but activity not obeying domains in barrel cortex-- problem with spatial sampling in the xy and the z for this study? -![**Figure 1.** Calcium domains throughout neonatal mouse isocortex. **a** Experimental schematic. **b** Single image frame showing calcium domains in both hemispheres at P3 and automatically detected domain masks. **c** Domain overlay map for a single 10 min recording. 3D binary masks were flattened for each domain and colored by time and transparently overlaid. Notice the non-uniform distribution of boundaries and color intensities across each hemisphere, as well as local maxima and minima that indicate matched areal boundaries bilaterally. **d** Histograms showing the distribution of spatial diameters and durations for calcium domains.](figure1.png) +![**Figure 1.** Calcium domains throughout neonatal mouse isocortex. **a** Experimental schematic. **b** Single image frame showing calcium domains in both hemispheres at P3 and automatically detected domain masks. **c** Functional activity map at P3. Based on pixel activation frequency from detected domains in a single 10 min recording. Map is overlaid on cortical areal parcellations. Notice localized maxima and minima of functional activity between areas that approximate known anatomical cortical area boundaries and the mirroring of map structure bilaterally. **d** Histograms showing the distribution of spatial diameters and durations for calcium domains.](figure1.png) metric | mean | min | max | unit ------------- | ----- | ---- | ------ | -------------------- @@ -113,7 +113,7 @@ lenActvFraction>0 | fracCorr | timeCorr_s | fracCorrPos | timeCorrPos_s | fracCo # Conclusions * **Ongoing activity in developing cortex is not random**-- specifically coordinated in space and time within and among cortical areas between the hemispheres -* BRAIN initiative +* ~~BRAIN initiative (for cover letter to the editor)~~ - this work aids at least a couple of the 9 preliminary aims of the Brain project * template for assessing altered functional dynamics in models for neurological disorders @@ -128,55 +128,60 @@ lenActvFraction>0 | fracCorr | timeCorr_s | fracCorrPos | timeCorrPos_s | fracCo -